Virgin Hotels opened its first property in Chicago in 2015, followed by hotels in Dallas, Nashville and New Orleans.
The group also debuted in Las Vegas last year, with the conversion of the former Hard Rock Hotel and Casino in Las Vegas.
Commenting on the news James Bermingham, chief executive officer of Virgin Hotels, said:
“We’re thrilled to share our second hotel in the UK in a completely different city, Glasgow. Virgin Hotels Glasgow will feature neighbourhood-driven design and various restaurant and bar offerings.
“We truly believe the hotel will be the ideal hub for visitors wanting to soak up this vibrant city while enjoying authentic experiences. Glasgow showcases fantastic museums and galleries, a thriving music scene, and innovative food and drinks outlets, and we cannot wait to open.”